Nely was born and raised in Puerto Rico. His parents are from the Dominican Republic. He began with music at five years old, playing drums in his local church. At the age of 14 he began experimenting with reggaeton. He quickly established himself as the top producer for some of the music industry's biggest stars
Nely was part of the reggaeton explosion, contributing to their highest selling albums including Mas Flow 2 and Wisin & Yandel's Pa'l Mundo. He produced many hits including Gansta Zone (Daddy Yankee & Snoop Dogg), Conteo (Don Omar), Rakata (Wisin & Yandel), Noche de Travesura (Hector "El Father" & Divino), Cuanto Tengo Que Esperar (Zion & Lennox), Contacto (Yaviah), Burn It Up (R. Kelly) and Obsession (Frankie J).
Nely founded the label Artillery Music Inc/Sony Music in which fellow producer Tainy is also a member.